Depression is not caused by a ‘chemical imbalance’ in the brain, say scientists

There is no clear evidence that depression is caused by low serotonin levels, research suggests.

The new review, which analysed existing studies, suggests the condition is not likely caused by a chemical imbalance, and calls into question what antidepressants do.

Researchers say their findings are important as studies show that as many as 85-90% of the public believes that depression is caused by low serotonin or a chemical imbalance.

Most antidepressants are selective serotonin reuptake inhibitors (SSRIs), and were originally said to work by correcting abnormally low serotonin levels.